Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy

摘要

T-cell prolymphocytic leukemia is a rare aggressive lymphoproliferative disease with a mature T-cell phenotype and characteristic genomic rearrangements of 14q11. This study identifies numerous new potential target genes in common breakpoints, deletions and regions of acquired uniparental disomy.